KÆMPE aftale om et anti depressions stof
Her til morgen har Targacept annonceret en gigantisk aftale med AstraZeneca. Det drejer sig om stoffet TC-5214. Det er et stof der retter sig mod de ca 50-60% af depressive personer der ikke har gavn af de mest solgte stoffer fra SSRI klassen. TC-5214 skal så tages sammen med et SSRI stof, f.eks Cipralex fra Lundbeck. Og denne kombination har vist utrolige gode resultater i et fase 2b studie. Så stoffet er klar til at starte fase 3 medio 2010
Lidt om økonomien i aftalen. Og hold nu godt fast
Upfront $200 mio
Udviklings, godkendelse og første salgs milestones $540 mio
Yderligere salgs milestones $500 mio
Targacept kan opnå 2-cifrede royalties. (gætter på et max omkring 22%)
Targacept har option på co-promote i snæver udvalgt område (formentligt sygehusene)
AstraZeneca skal betale 80% af alle fremtidige udviklings udgifter mens Targacept står for resten.
Det er specielt upfront betalingen jeg hæfter mig ved. Jeg kan ganske enkelt ikke erindre et andet small molucle stof har opnået SÅ stor en upront betaling. Så sent som i går snakkede jeg med akademikeren om hvorledes upfront betalinger "normalt" bliver struktureret. "Normalt" så får man gerne dækket de udgifter der hidtil har været afholdt i programmet + et mindre tillæg på måske op mod 50%. Men da Targacept max har brugt $50 mio på udviklingen (nok tættere på $30 mio) så får de altså mindst 300% men reelt set nok op mod 600% betaling. Det har jeg altså aldrig hørt om før når vi trods alt kun snakker et klar til fase 3 stof. For der er jo stadig en stor risiko forbundet med stoffet. Så det er helt vildt det her.
Targacept beskæftiger sig UDELUKKENDE med nachr (nikotin receptorer). Det er samme target hvor Neurosearch også har et af deres største satsnings områder og hvor ABT894, ABT560 og NSD761 stammer fra. TC-5214 er et såkaldt nachr alfa 4 beta 2 stof. Og Neurosearch er også langt i forskningen omkring udvælgelsen af et lignende stof mod depression.
I starten af juli kostede en Targacept aktie $2.37. I går lukkede den i $23.5. I aften lukker den formentligt i omegnen af $30.
Vh
T.
AstraZeneca and Targacept Form Global Collaboration and License Agreement for Late-stage Investigational Product TC-5214 for the Treatment of Major Depressive Disorder
LONDON & WINSTON-SALEM, N.C., Dec 03, 2009 (BUSINESS WIRE) -- AstraZeneca and Targacept, Inc. today announced a collaboration and license agreement for the global development and commercialization of TC-5214, Targacept's late-stage investigational product for major depressive disorder (MDD). TC-5214, which recently completed a phase IIb clinical trial, is a nicotinic channel blocker that is thought to treat depression by modulating the activity of various neuronal nicotinic receptor (NNR) subtypes.
Major Depressive Disorder is a common illness, affecting approximately 42 million people worldwide, and the global antidepressant market is valued at over $20 billion. Serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed class of drugs for depression, but many patients fail to respond adequately. The NIMH STAR*D study suggests that approximately 63 percent of patients do not achieve remission with first-line SSRI treatment.
Under the agreement, AstraZeneca will make an upfront payment to Targacept of $200 million upon effectiveness and up to an additional $540 million if specified development, regulatory and first commercial sale milestones are achieved. Targacept will also be eligible to receive up to $500 million if specified sales related milestones are achieved as well as significant stepped double-digit royalties on net sales worldwide. Targacept has retained an option for a co-promotion of TC-5214 to a limited target physician audience in the US. Effectiveness of the agreement is contingent on expiration or termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act.
AstraZeneca and Targacept will jointly design a global phase III clinical program anticipated to begin in mid 2010 with the goal of filing a new drug application (NDA) with the US Food and Drug Administration (FDA) in 2012. TC-5214 is being developed as an adjunct to antidepressant therapy in adults with MDD who do not respond adequately to first-line antidepressant treatment. The companies will also initiate a phase II study exploring TC-5214 as a monotherapy for MDD. AstraZeneca will be responsible for 80% of the cost of the initial global development program, with Targacept responsible for the remaining 20%. AstraZeneca will be responsible for and will fund the costs of global commercialization of TC-5214, and will assume Targacept's manufacturing and supply agreements with third parties in relation to TC-5214. The agreement also provides for a specified period for the parties to negotiate a potential multi-year research program that would be conducted by Targacept to identify and develop additional NNR Therapeutics for MDD and possibly other indications.
David Brennan, Chief Executive Officer of AstraZeneca said: "The opportunity to improve treatment in depression is a large one, both commercially and in terms of benefits for patients. It's an area both AstraZeneca and Targacept know well and I'm pleased to be adding another late stage project to our pipeline."
J. Donald deBethizy, Ph.D., President and Chief Executive Officer of Targacept, said: "We are delighted to have selected AstraZeneca to work with us to meet our goal of advancing TC-5214 into late-stage development and bringing a new mechanistic approach for the treatment of depression to the millions of patients who do not respond well to first-line antidepressant therapy and need relief. Targacept and AstraZeneca have an established track record of successful collaboration and today's agreement demonstrates our shared dedication to excellence in the field of neuroscience."
Targacept and AstraZeneca previously entered into a global collaboration focused on cognitive disorders in 2005. Three product candidates in the collaboration are currently in clinical development; including AZD3480 for attention deficit/hyperactivity disorder (ADHD), AZD1446 planned for Alzheimer's disease, and TC-5619, for cognitive dysfunction in schizophrenia.
About TC-5214
Scientific evidence suggests that depressive symptoms are associated with an overstimulation of NNRs and other receptors in the brain that are activated by the neurotransmitter acetylcholine. This overstimulation is referred to as increased cholinergic tone. TC-5214 has properties that modulate forms of NNR subtypes thought to be involved in the increased cholinergic tone associated with depression. In particular, TC-5214 blocks certain NNR channels. TC-5214 is the subject of issued patents that expire in the US and all major EU markets in 2020 and 2019, respectively. Additional patent term may be available via applicable patent term restoration laws. Targacept would be required to pay a percentage of amounts received from AstraZeneca under the agreement with respect to TC-5214 to the University of South Florida Research Foundation under the terms of an existing license agreement.
About TC-5214 phase IIb data
The recently completed phase II trial for TC-5214 in subjects who did not respond adequately to first-line treatment with the SSRI citalopram alone showed the primary outcome measure [mean change between treatment (TC-5214 + citalopram) and placebo (Placebo + citalopram) from baseline on the HAM-D*] and all secondary measures were statistically significant in favor of TC-5214 on an intent to treat basis. During this phase II trial, the most frequent adverse events were headache, dizziness and constipation. There was no clinically significant difference between the dose groups in discontinuations due to adverse events.
About Targacept
Targacept is a clinical-stage biopharmaceutical company that discovers and develops NNR Therapeutics(TM), a new class of drugs for the treatment of central nervous system diseases and disorders, in support of its vision of building health and restoring independence for patients. Targacept has clinical-stage product candidates in development for major depressive disorder, attention deficit/hyperactivity disorder, Alzheimer's disease and cognitive dysfunction in schizophrenia, as well as multiple preclinical programs. In addition to its collaboration with AstraZeneca, Targacept has a strategic alliance with GlaxoSmithKline. Targacept's news releases are available on its website at www.targacept.com.
NNR Therapeutics(TM) is a trademark of Targacept, Inc.
About AstraZeneca
Her til morgen har Targacept annonceret en gigantisk aftale med AstraZeneca. Det drejer sig om stoffet TC-5214. Det er et stof der retter sig mod de ca 50-60% af depressive personer der ikke har gavn af de mest solgte stoffer fra SSRI klassen. TC-5214 skal så tages sammen med et SSRI stof, f.eks Cipralex fra Lundbeck. Og denne kombination har vist utrolige gode resultater i et fase 2b studie. Så stoffet er klar til at starte fase 3 medio 2010
Lidt om økonomien i aftalen. Og hold nu godt fast
Upfront $200 mio
Udviklings, godkendelse og første salgs milestones $540 mio
Yderligere salgs milestones $500 mio
Targacept kan opnå 2-cifrede royalties. (gætter på et max omkring 22%)
Targacept har option på co-promote i snæver udvalgt område (formentligt sygehusene)
AstraZeneca skal betale 80% af alle fremtidige udviklings udgifter mens Targacept står for resten.
Det er specielt upfront betalingen jeg hæfter mig ved. Jeg kan ganske enkelt ikke erindre et andet small molucle stof har opnået SÅ stor en upront betaling. Så sent som i går snakkede jeg med akademikeren om hvorledes upfront betalinger "normalt" bliver struktureret. "Normalt" så får man gerne dækket de udgifter der hidtil har været afholdt i programmet + et mindre tillæg på måske op mod 50%. Men da Targacept max har brugt $50 mio på udviklingen (nok tættere på $30 mio) så får de altså mindst 300% men reelt set nok op mod 600% betaling. Det har jeg altså aldrig hørt om før når vi trods alt kun snakker et klar til fase 3 stof. For der er jo stadig en stor risiko forbundet med stoffet. Så det er helt vildt det her.
Targacept beskæftiger sig UDELUKKENDE med nachr (nikotin receptorer). Det er samme target hvor Neurosearch også har et af deres største satsnings områder og hvor ABT894, ABT560 og NSD761 stammer fra. TC-5214 er et såkaldt nachr alfa 4 beta 2 stof. Og Neurosearch er også langt i forskningen omkring udvælgelsen af et lignende stof mod depression.
I starten af juli kostede en Targacept aktie $2.37. I går lukkede den i $23.5. I aften lukker den formentligt i omegnen af $30.
Vh
T.
AstraZeneca and Targacept Form Global Collaboration and License Agreement for Late-stage Investigational Product TC-5214 for the Treatment of Major Depressive Disorder
LONDON & WINSTON-SALEM, N.C., Dec 03, 2009 (BUSINESS WIRE) -- AstraZeneca and Targacept, Inc. today announced a collaboration and license agreement for the global development and commercialization of TC-5214, Targacept's late-stage investigational product for major depressive disorder (MDD). TC-5214, which recently completed a phase IIb clinical trial, is a nicotinic channel blocker that is thought to treat depression by modulating the activity of various neuronal nicotinic receptor (NNR) subtypes.
Major Depressive Disorder is a common illness, affecting approximately 42 million people worldwide, and the global antidepressant market is valued at over $20 billion. Serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed class of drugs for depression, but many patients fail to respond adequately. The NIMH STAR*D study suggests that approximately 63 percent of patients do not achieve remission with first-line SSRI treatment.
Under the agreement, AstraZeneca will make an upfront payment to Targacept of $200 million upon effectiveness and up to an additional $540 million if specified development, regulatory and first commercial sale milestones are achieved. Targacept will also be eligible to receive up to $500 million if specified sales related milestones are achieved as well as significant stepped double-digit royalties on net sales worldwide. Targacept has retained an option for a co-promotion of TC-5214 to a limited target physician audience in the US. Effectiveness of the agreement is contingent on expiration or termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act.
AstraZeneca and Targacept will jointly design a global phase III clinical program anticipated to begin in mid 2010 with the goal of filing a new drug application (NDA) with the US Food and Drug Administration (FDA) in 2012. TC-5214 is being developed as an adjunct to antidepressant therapy in adults with MDD who do not respond adequately to first-line antidepressant treatment. The companies will also initiate a phase II study exploring TC-5214 as a monotherapy for MDD. AstraZeneca will be responsible for 80% of the cost of the initial global development program, with Targacept responsible for the remaining 20%. AstraZeneca will be responsible for and will fund the costs of global commercialization of TC-5214, and will assume Targacept's manufacturing and supply agreements with third parties in relation to TC-5214. The agreement also provides for a specified period for the parties to negotiate a potential multi-year research program that would be conducted by Targacept to identify and develop additional NNR Therapeutics for MDD and possibly other indications.
David Brennan, Chief Executive Officer of AstraZeneca said: "The opportunity to improve treatment in depression is a large one, both commercially and in terms of benefits for patients. It's an area both AstraZeneca and Targacept know well and I'm pleased to be adding another late stage project to our pipeline."
J. Donald deBethizy, Ph.D., President and Chief Executive Officer of Targacept, said: "We are delighted to have selected AstraZeneca to work with us to meet our goal of advancing TC-5214 into late-stage development and bringing a new mechanistic approach for the treatment of depression to the millions of patients who do not respond well to first-line antidepressant therapy and need relief. Targacept and AstraZeneca have an established track record of successful collaboration and today's agreement demonstrates our shared dedication to excellence in the field of neuroscience."
Targacept and AstraZeneca previously entered into a global collaboration focused on cognitive disorders in 2005. Three product candidates in the collaboration are currently in clinical development; including AZD3480 for attention deficit/hyperactivity disorder (ADHD), AZD1446 planned for Alzheimer's disease, and TC-5619, for cognitive dysfunction in schizophrenia.
About TC-5214
Scientific evidence suggests that depressive symptoms are associated with an overstimulation of NNRs and other receptors in the brain that are activated by the neurotransmitter acetylcholine. This overstimulation is referred to as increased cholinergic tone. TC-5214 has properties that modulate forms of NNR subtypes thought to be involved in the increased cholinergic tone associated with depression. In particular, TC-5214 blocks certain NNR channels. TC-5214 is the subject of issued patents that expire in the US and all major EU markets in 2020 and 2019, respectively. Additional patent term may be available via applicable patent term restoration laws. Targacept would be required to pay a percentage of amounts received from AstraZeneca under the agreement with respect to TC-5214 to the University of South Florida Research Foundation under the terms of an existing license agreement.
About TC-5214 phase IIb data
The recently completed phase II trial for TC-5214 in subjects who did not respond adequately to first-line treatment with the SSRI citalopram alone showed the primary outcome measure [mean change between treatment (TC-5214 + citalopram) and placebo (Placebo + citalopram) from baseline on the HAM-D*] and all secondary measures were statistically significant in favor of TC-5214 on an intent to treat basis. During this phase II trial, the most frequent adverse events were headache, dizziness and constipation. There was no clinically significant difference between the dose groups in discontinuations due to adverse events.
About Targacept
Targacept is a clinical-stage biopharmaceutical company that discovers and develops NNR Therapeutics(TM), a new class of drugs for the treatment of central nervous system diseases and disorders, in support of its vision of building health and restoring independence for patients. Targacept has clinical-stage product candidates in development for major depressive disorder, attention deficit/hyperactivity disorder, Alzheimer's disease and cognitive dysfunction in schizophrenia, as well as multiple preclinical programs. In addition to its collaboration with AstraZeneca, Targacept has a strategic alliance with GlaxoSmithKline. Targacept's news releases are available on its website at www.targacept.com.
NNR Therapeutics(TM) is a trademark of Targacept, Inc.
About AstraZeneca
3/12 2009 14:12 Sukkeralf 0
23011 Imponerende aftale må man sige 
Det lader heller ikke til at den høje upfront betaling inkludere aktier, så det er rigtig flot !
Ved du om NS ligeledes går efter kombinationsbehandling ?
Mvh
Sukkeralf
Mvh
Det lader heller ikke til at den høje upfront betaling inkludere aktier, så det er rigtig flot !
Ved du om NS ligeledes går efter kombinationsbehandling ?
Mvh
Sukkeralf
Mvh
3/12 2009 14:36 troldmanden 023013 Ja den er imponerende på alle tænkelige måder.
Nej jeg er ikke helt klar over om der er tale om kombinations eller singel agent de går efter. Det sidste vil selvfølgelig være det bedste. Men hælder nok mest til det første.
Men her er en få mdr gammel publikation hvor de er nået frem til der er tale om at det er antagonist mekanismen der har en virkning. Men det synes både at være alfa 4 beta 2, og alfa 7 der er involveret
http://www.ncbi.nlm.nih.gov/pubmed/18583432?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5
Nej jeg er ikke helt klar over om der er tale om kombinations eller singel agent de går efter. Det sidste vil selvfølgelig være det bedste. Men hælder nok mest til det første.
Men her er en få mdr gammel publikation hvor de er nået frem til der er tale om at det er antagonist mekanismen der har en virkning. Men det synes både at være alfa 4 beta 2, og alfa 7 der er involveret
http://www.ncbi.nlm.nih.gov/pubmed/18583432?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5
