Click
Chat
 
Du kan vedhæfte PDF, JPG, PNG, DOC(X), XLS(X) og TXT-filer. Klik på ikonet, vælg fil og vent til upload er færdig før du indsender eller uploader endnu en fil.
60
Vedhæft Send
Historik

Vælg chat via ovenstående menu
Luk reklame

      

Partner aftalen Genmab længes efter


43772 troldmanden 7/7 2011 18:23
Oversigt

Bristol-Myers Squibb indgik i går en aftale med Innate Pharma om deres fase 1 cancer stof IPH2102. Upfront $35 mio og potentielle milestones på $430 mio. Det er nok det lejde Genmab sigter mod for CD38. Og bestemt et selskabet har behov for at komme ud afderes kursmæige dødsvande. Et dødsvande der nu igen ser ud til at få kursen til at sive til der kommer nyt.

http://pharmalive.com/news/index.cfm?articleID=792257..



7/7 2011 20:01 gentogen 143775



Celgene måske (lenalidomide)?

Results: Daratumumab-dependent cell-mediated cytotoxicity of purified primary multiple myeloma cells, as well as of the UM-9 cell line, was significantly augmented by lenalidomide pre-treatment of the effector cells derived from peripheral blood mononuclear cells from healthy individuals. More importantly, we demonstrated a clear synergy between lenalidomide and daratumumab-induced antibody-dependent cell-mediated cytotoxicity directly in the bone marrow mononuclear cells of multiple myeloma patients, indicating that lenalidomide can also potentiate the daratumumab-dependent lysis of myeloma cells by activating the autologous effector cells within the natural environment of malignant cells. Finally, daratumumab-dependent cell-mediated cytotoxicity was significantly up-regulated in peripheral blood mononuclear cells derived from 3 multiple myeloma patients during lenalidomide treatment.

Conclusions: Our results indicate that powerful and complementary effects may be achieved by combining lenalidomide and daratumumab in the clinical management of multiple myeloma.



TRÅDOVERSIGT